Altered activity of the medial prefrontal cortex and amygdala during acquisition and extinction of an active avoidance task
Altered medial prefrontal cortex (mPFC) and amygdala function is associated with anxiety-related disorders.While the mPFC-amygdala pathway has a clear role in fear conditioning, these structures are also involved in active avoidance.Given that avoidance perseveration represents a core symptom of anxiety disorders, the neural substrate of avoidance,